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More than 7000 persons have participated to EPOGH in Europe. This project was initiated by Prof. Jan Staessen (Catholic University of Leuven, Belgium). EPOGH has resulted in over 100 scientific publications in the field of hypertension (high blood pressure) and genetics. It has substantially participated to the breakthrough established in 2009 in high blood pressure research, identifying 13 loci (regions of the chromosome) that are associated with high blood pressure. Of note, one of the SKIPOGH-investigators was first author of this paper.
 
More than 7000 persons have participated to EPOGH in Europe. This project was initiated by Prof. Jan Staessen (Catholic University of Leuven, Belgium). EPOGH has resulted in over 100 scientific publications in the field of hypertension (high blood pressure) and genetics. It has substantially participated to the breakthrough established in 2009 in high blood pressure research, identifying 13 loci (regions of the chromosome) that are associated with high blood pressure. Of note, one of the SKIPOGH-investigators was first author of this paper.
  
The goal of SKIPOGH is to screen 1200 Swiss inhabitants, from approximately 400 families. A simple, non stratified sample of subjects has been drawn from lists of inhabitants provided by the population registers of the three cities. A letter inviting the addressee to participate is sent, and subjects are contacted within 14 days by one of the staff members. The following inclusion criteria are applied: (a) written informed consent; (b) minimum age 18 years; (c) willingness to take part in the examination and donate blood sample; (d) Caucasian origin, defined as having both parents and grandparents born in a restricted list of countries (available from the authors) (e) at least one, and preferably three, first degree family members also willing to participate. The family members are contacted in a similar way, and an appointment for a study visit is set individually with each family member. The SKIPOGH study was approved by the Institutional Ethics Committee of the Universities of Bern, Geneva and Lausanne. SKIPOGH has started recruitment in January 2010. In July 2011, a total number of 600 persons was reached. Recruitment shall continue until April 2013.
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The goal of SKIPOGH was to screen 1200 Swiss inhabitants, from approximately 400 families. A simple, non stratified sample of subjects has been drawn from lists of inhabitants provided by the population registers of the three cities. A letter inviting the addressee to participate is sent, and subjects are contacted within 14 days by one of the staff members. The following inclusion criteria are applied: (a) written informed consent; (b) minimum age 18 years; (c) willingness to take part in the examination and donate blood sample; (d) Caucasian origin, defined as having both parents and grandparents born in a restricted list of countries (available from the authors) (e) at least one, and preferably three, first degree family members also willing to participate. The family members are contacted in a similar way, and an appointment for a study visit is set individually with each family member.
  
The SKIPOGH study has 4 field centers ('''Lausanne, Geneva, Bern, Zurich''') and the data coordinating center in Lausanne.
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The SKIPOGH study has 3 field centers (in the university hospitals of Lausanne, Geneva, Bern) and one data coordinating center in Lausanne.
  
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The  study was approved by the Institutional Ethics Committee of the Universities of Bern, Geneva and Lausanne.
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SKIPOGH recruitment started in January 2009. In Lausanne, the recruitment was finished in March 2012, In Geneva in September 2012, in Bern in May 2013.
 
The [http://www.staessen.net European Coordinating Center] is in Leuven under the direction of Prof. Staessen.
 
The [http://www.staessen.net European Coordinating Center] is in Leuven under the direction of Prof. Staessen.

Revision as of 10:03, 22 December 2015

Plus de 7000 personnes ont participé à EPOGH en Europe. Plus de 100 publications dans le domaine de l’hypertension (hypertension artérielle) et de la génétique ont résulté d’EPOGH. Cela a considérablement contribué à l’avancée des recherches sur l’hypertension artérielle établie en 2009 qui a permis d’identifier 13 régions du chromosome associé à l’hypertension. Soulignons le fait que l’un des investigateurs de SKIPOGH était premier auteur de cette publication.

L’objectif de SKIPOGH était d’examiner 1200 habitants de Suisse appartenant à approximativement 400 familles. Un échantillon simple, non stratifié, des sujets a été établi à partir de listes d’habitants fournies par le recensement de la population des trois sites participants (les cas index des familles ont été sélectionnés dans l’étude de population CoLaus à Lausanne et Bus Santé à Genève et dans la population du canton à Berne). Une lettre invitant les personnes concernées à participer a été envoyée et les sujets ont été contactés après 14 jours par un des membres de l’équipe. Les critères d’inclusion suivants ont été appliqués : (a) signature d’un consentement éclairé; (b) âge minimum 18 ans ; (c) volonté de participer aux examens médicaux et au don d’échantillons de sang ; (d) origine Européenne, définie comme ayant les deux parents et grands-parents nés dans une liste restreinte de pays (disponible chez les investigateurs) ; (e) au moins un, et de préférence trois membres de la famille au premier degré qui consentent à participer. Les membres de la famille sont contactés de manière similaire et un rendez-vous pour une visite est fixé individuellement avec chaque membre de la famille.

Comme tout projet de recherche clinique, l’étude a été approuvée par les commissions d’éthique des cantons de Berne, Genève et Vaud (Lausanne).

Le recrutement dans le cadre de SKIPOGH 1 a commencé au mois d’octobre 2009. Le recrutement s’est terminé en avril 2012 à Lausanne, en novembre 2012 à Genève, et en mai 2013 à Berne.

L’étude SKIPOGH regroupe 3 centres (dans les hôpitaux universitaires de Lausanne, Genève et Berne). Le centre de Lausanne est également celui qui coordonne la récolte des données pour l’ensemble des centres.

Le European Coordinating Center se trouve à Louvain sous la direction du Prof. Staessen.




Über 7000 Personen haben bei der EPOGH-Studie in Europa teilgenommen. Die daraus resultierenden Erkenntnisse haben bereits zu vielen neuen Erkenntnissen geführt, die in mehr als 100 Publikationen festgehalten wurden. In der genetischen Erbsubstanz, der DNS, konnten 13 Orte identifiziert werden, die für die Blutdruckregulation wichtig sind. Diese bahnbrechenden Erkenntnisse der SKIPOGH-Studienleiterin, Prof. Murielle Bochud, sind für die gegenwärtige Studie eine bedeutende Grundlage.

In der SKIPOGH-Untersuchung sollen 1200 Teilnehmer aus ca. 400 Familien untersucht werden, welche die normale schweizerische Bevölkerung repräsentieren. An dieser Studie sind 3 Universitätsspitäler (Lausanne, Genf, Bern) beteiligt. Das zentrale Studienmanagement befindet sich in Lausanne. Die ethische Begutachtung einer solchen Studie ist sehr wichtig und fand in den jeweiligen Ethikkomissionen mit positivem Bescheid statt. Teilnehmer wurden auf Listen der Einwohnerämter der 3 Städte basierend ausgesucht und Einladungen per Post versandt. 14 Tage später wurden die Personen durch das Studienpersonal telefonisch kontaktiert. Teilnehmen durften die angefragten Personen, wenn bestimmte folgende Kriterien erfüllt waren.

Die ersten Teilnehmer konnten im Januar 2010 begrüsst werden. Halbzeit war im Juli 2011. Lausanne konnte im April 2012, Genf im November 2012 und Bern im März 2013 die letzten Teilnehmer einschliessen und mit der Auswertung beginnen.

Das European Coordinating Center ist in Löwen unter der Leitung von Prof. Staessen.




More than 7000 persons have participated to EPOGH in Europe. This project was initiated by Prof. Jan Staessen (Catholic University of Leuven, Belgium). EPOGH has resulted in over 100 scientific publications in the field of hypertension (high blood pressure) and genetics. It has substantially participated to the breakthrough established in 2009 in high blood pressure research, identifying 13 loci (regions of the chromosome) that are associated with high blood pressure. Of note, one of the SKIPOGH-investigators was first author of this paper.

The goal of SKIPOGH was to screen 1200 Swiss inhabitants, from approximately 400 families. A simple, non stratified sample of subjects has been drawn from lists of inhabitants provided by the population registers of the three cities. A letter inviting the addressee to participate is sent, and subjects are contacted within 14 days by one of the staff members. The following inclusion criteria are applied: (a) written informed consent; (b) minimum age 18 years; (c) willingness to take part in the examination and donate blood sample; (d) Caucasian origin, defined as having both parents and grandparents born in a restricted list of countries (available from the authors) (e) at least one, and preferably three, first degree family members also willing to participate. The family members are contacted in a similar way, and an appointment for a study visit is set individually with each family member.

The SKIPOGH study has 3 field centers (in the university hospitals of Lausanne, Geneva, Bern) and one data coordinating center in Lausanne.

The study was approved by the Institutional Ethics Committee of the Universities of Bern, Geneva and Lausanne.

SKIPOGH recruitment started in January 2009. In Lausanne, the recruitment was finished in March 2012, In Geneva in September 2012, in Bern in May 2013. The European Coordinating Center is in Leuven under the direction of Prof. Staessen.

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